Assessment of restless legs syndrome—Methodological approaches for use in practice and clinical trials
Identifieur interne : 003010 ( Main/Exploration ); précédent : 003009; suivant : 003011Assessment of restless legs syndrome—Methodological approaches for use in practice and clinical trials
Auteurs : Ralf Kohnen [Allemagne] ; Richard P. Allen [États-Unis] ; Heike Benes [Allemagne] ; Diego Garcia-Borreguero [Espagne] ; Wayne A. Hening [États-Unis] ; Karin Stiasny-Kolster [Allemagne] ; Marco Zucconi [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Activities of Daily Living, Clinical Trials as Topic, Clinical trial, Endpoint Determination, Evaluation scale, Humans, Nervous system diseases, Quality of Life, Quality of life, Questionnaire, Restless Legs Syndrome (complications), Restless Legs Syndrome (diagnosis), Restless Legs Syndrome (therapy), Restless legs syndrome, Severity of Illness Index, Surgical approach, quality of life, questionnaire, rating scale, restless legs syndrome, severity.
- MESH :
- complications : Restless Legs Syndrome.
- diagnosis : Restless Legs Syndrome.
- therapy : Restless Legs Syndrome.
- Activities of Daily Living, Clinical Trials as Topic, Endpoint Determination, Humans, Quality of Life, Severity of Illness Index.
Abstract
The Restless Legs Syndrome (RLS) is a sensorimotor disorder that has only recently been extensively investigated by validated methods. Following the first presentation of diagnostic criteria by the International RLS Study Group in 1995, several methods were specifically developed for clinical trials in RLS or adapted from other areas of medicine and health sciences. We present a critical overview on validated methods to assess (1) severity of RLS symptoms [International RLS Rating Scale (IRLS), John Hopkins RLS Severity Scale (JHRLSSS), the RLS‐6 scales, and the investigtor‐based Clincial Global Impressions (CGI)]; (2) quality of life [RLS Quality of Life Instrument (RLS‐QLI), Hopkins RLS Quality of Life Questionnaire (RLSQoL), and the RLS Quality of Life Questionnaire (QoL‐RLS)]; (3) sleep disturbances and sudden onset of sleep; (4) sleep laboratory methods (polysomnography, limb activity monitoring by actigraphy) to evaluate sleep and periodic leg movements (including the “suggested immobilization test”); and (5) severity of augmentation (Augmentation Severity Rating Scale, ASRS). It is concluded that several validated methods are available to investigate the main features of RLS in practice and in clinical trials; however, further developments are needed to address new questions like the consequences of RLS on life functioning in areas such as ability to travel, days missed at work or impaired work performance. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21588
Affiliations:
- Allemagne, Espagne, Italie, États-Unis
- Communauté de Madrid, District de Giessen, Hesse (Land), Maryland, New Jersey
- Madrid, Marbourg
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Le document en format XML
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Following the first presentation of diagnostic criteria by the International RLS Study Group in 1995, several methods were specifically developed for clinical trials in RLS or adapted from other areas of medicine and health sciences. We present a critical overview on validated methods to assess (1) severity of RLS symptoms [International RLS Rating Scale (IRLS), John Hopkins RLS Severity Scale (JHRLSSS), the RLS‐6 scales, and the investigtor‐based Clincial Global Impressions (CGI)]; (2) quality of life [RLS Quality of Life Instrument (RLS‐QLI), Hopkins RLS Quality of Life Questionnaire (RLSQoL), and the RLS Quality of Life Questionnaire (QoL‐RLS)]; (3) sleep disturbances and sudden onset of sleep; (4) sleep laboratory methods (polysomnography, limb activity monitoring by actigraphy) to evaluate sleep and periodic leg movements (including the “suggested immobilization test”); and (5) severity of augmentation (Augmentation Severity Rating Scale, ASRS). It is concluded that several validated methods are available to investigate the main features of RLS in practice and in clinical trials; however, further developments are needed to address new questions like the consequences of RLS on life functioning in areas such as ability to travel, days missed at work or impaired work performance. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Espagne</li><li>Italie</li><li>États-Unis</li></country><region><li>Communauté de Madrid</li><li>District de Giessen</li><li>Hesse (Land)</li><li>Maryland</li><li>New Jersey</li></region><settlement><li>Madrid</li><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Kohnen, Ralf" sort="Kohnen, Ralf" uniqKey="Kohnen R" first="Ralf" last="Kohnen">Ralf Kohnen</name></noRegion><name sortKey="Benes, Heike" sort="Benes, Heike" uniqKey="Benes H" first="Heike" last="Benes">Heike Benes</name><name sortKey="Stiasny Olster, Karin" sort="Stiasny Olster, Karin" uniqKey="Stiasny Olster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Allen, Richard P" sort="Allen, Richard P" uniqKey="Allen R" first="Richard P." last="Allen">Richard P. Allen</name></region><name sortKey="Hening, Wayne A" sort="Hening, Wayne A" uniqKey="Hening W" first="Wayne A." last="Hening">Wayne A. Hening</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Garcia Orreguero, Diego" sort="Garcia Orreguero, Diego" uniqKey="Garcia Orreguero D" first="Diego" last="Garcia-Borreguero">Diego Garcia-Borreguero</name></region></country><country name="Italie"><noRegion><name sortKey="Zucconi, Marco" sort="Zucconi, Marco" uniqKey="Zucconi M" first="Marco" last="Zucconi">Marco Zucconi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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